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Exacerbation of GERD with initial use of GLP-1 therapies may be managed with short-term use of proton pump inhibitors or H2 receptor antagonists, noting that weight reduction achieved with GLP-1 therapies over the long-term often leads to improvement in GERD symptoms [34,35]
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In addition, the high cost of GLP-1 therapies remains a barrier, especially in markets with limited insurance coverage or constrained healthcare budgets The annual cost of treatment with drugs such as Wegovy or Zepbound can exceed several thousand dollars, which may limit accessibility for patients without comprehensive health coverage
